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veterinary Drug Residue working group

Don't miss 2022 NACRW!

Working Group meetings open to all attendees!

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You can still participate!

Participants can view recorded presentations and listen to discussions after the meeting.  See the program for instructions.

July 25, 2022 VDR Working Group Meeting

  

AGENDA for the Veterinary Drug Residue Working Group Meeting


10:45 – 11:05 am 


Progress of the VDR Collaborative Study  


Maïwenn Le Floch, Anses-Fougères, National and EU Reference Laboratory for VDR in Food; Fougères, France; maiwenn.lefloch@anses.fr   


Thanks to the evolution of instruments that increase in sensitivity and detection capacity, it is becoming interesting to implement multi-class methods of several hundred substances in control laboratories. Developments of these kind of methods are already a topic of concern worldwide, and it is relevant to highlight their use oriented towards official control. It is with this in mind that the NACRW Vet Drug Residue Working Group started to talk about the organization in 2019 of an inter-laboratory collaborative study to evaluate the screening practices for veterinary drug residues carried out using various new generation mass spectrometry devices. The main goal of this study is to evaluate and establish general identification criteria for LC-MS methods using empirical data to minimize rates of false positives and negatives. Three “Rounds” are planned by three different leading labs, each of them selecting two different commodities. In each Round, the study coordinator has to prepare and ship a tray of autosampler vials consisting of spiked final extracts and calibration standards. The receiving laboratories have to analyze the extracts in a prescribed sequence with their own method(s) that should include the 30 targeted drug analytes using LC-MS/MS and/or HRMS instrumentation. The organization of the Round 1 started in the fall of 2021 led by the laboratory of Anses-Fougères in France. During this meeting will be presented the evolution of the study over the past twelve months.   


11:05 – 11:25 am 


Stability of Veterinary Drugs  


Steven J. Lehotay, U.S. Department of Agriculture, Agricultural Research Service; Wyndmoor, PA  19038; USA. email: steven.lehotay@usda.gov  A stability study was conducted for 27 of the 30 veterinary drugs targeted in the collaborative study being conducted by the Veterinary Drugs Working Group.  The drug analytes were monitored over the course of a month at 10, 100, and 1,000 ng/g sample equivalents in the diluted aqueous final extracts for Round 2 in the study (chicken egg and 1/1 bovine liver/kidney).  Storage temperatures were -80, -18, 8, and 20 degrees C in the dark.  Nearly all of the drugs were stable for at least 30 days in frozen conditions, and few of the analytes were stable at room temperature, as will be shown in the brief presentation.      


11:25 - 11:45 am 


Insights into the new EU Implementing Regulation for Analytical Methods Performance for Veterinary Drug Residue Official Control in Food: CIR (EU) 2021/808  


Eric Verdon, Anses-Fougères, National and EU Reference Laboratory for VDR in Food; Fougères, France; eric.verdon@anses.fr  


In June 2021 was enforced into the EU a new Commission Implementing Regulation dedicated to update and repeal the old Decisions (EC) 2002/657 and (EC) 98/179 as regard to the performance of analytical methods for residues of pharmacologically active substances used in food-producing animals and on the interpretation of results as well as on the methods to be used for sampling. This presentation will aim at giving some insights on the new approaches inserted in this document and at comparing criteria with those from the 20-year-old former regulation.  


11:45 am – 12:15 pm 


Open Forum: Question and Answer Session for NACRW Veterinary Drugs Working Group


Sherri Turnipseed, FDA, Animal Drugs Research Center, Denver, CO, USA  A part of the 2022 Annual Meeting of the NACRW Veterinary Drugs Working Group there will be an open forum intended to facilitate discussion among the audience and core members of the Veterinary Working Group.  Questions relating to the ongoing collaborative study and other issues of interest to the group will be included.  All interested attendees are welcome to participate in the on-line discussion.     

The NACRW VDR WG is

launching a collaborative study

Regulatory food laboratory participation is requested in an international collaborative project. The goal is to evaluate identification criteria using LC-MS (triple quadrupole and/or high resolution) for multi-veterinary drug residues analysis.

For more information see the Letter of Invitation below. 

collaborative study "Letter of Invitation" AND schedule

Three rounds are planned, beginning in the Winter of 2022

Letter_of_Invitation (pdf)

Download

Schedule_of_Study_Activities (pdf)

Download

working group meeting PRESENTATIONS - JULY 2021

Annual meeting was held virtually in 2021

 

Monday, July 26, 2021

1:15 - 3:15 pm

Presentations (P1, P2, P3, P4) and Open Forum  discussed the optimal MS-based analyte identification criteria.  A collaborative study of multiple matrices and analytes is being planned to evaluate analyte identification criteria to minimize the rate of false positives and false negatives.

presentations

P1- Lehotay - Targeted_MS-MS_ID (pdf)

Download

P2 - Kaufmann - Optimal_HRMS_ID (pdf)

Download

P3 - Turnipseed - Collb_Study_Parameters (pdf)

Download

P4 - Verdon - Launching_Collab_Project (pdf)

Download

Sunday, July 21, 2019 presentations & VDWG Notes

2019-07-22_NACRW 2019 VDR WG MEETING of JULY 22 2019 (pdf)Download
2019-07-21_NACRW2019- NACRW VDR WG MEETING SUNDAY 21 JULY (pdf)Download
2019-07-21_VDWGAttendee List (pdf)Download

working group activities



                

2022 MEETINGS   

  • April 4, 2022  

Virtual meeting

Planned program for July 2022 WG Meeting; presented results of stability studies for Round 2; discussed shipping of test materials and alternatives to reduce costs; collaborated on forms and reporting spreadsheets to harmonize for all 3 rounds.

  • February 14, 2022  

Virtual meeting

Discussed July 2022 Virtual meeting; updated information on potential collaborators; revised some study parameters; discussed documentation including instructions and spreadsheets; discussed the delivery of test materials.

  • January 24, 2022

Virtual meeting

Reviewed responses from possible collaborators, addressed their questions and established criteria for accepting laboratories to participate in the study. Evaluated stability studies.


PRIOR YEAR'S MEETINGS   


  • January 28, 2021

Reviewed study parameters, discussed introductory letter and "Call for Participants"; began developing a list of international laboratories who might participate; prepare protocol for first round. 

  • March  6, 2021

Discussed introductory letter and "Call for Participants"; began developing a list of official control international laboratories who might participate; prepare protocol for first round.

  • April 7, 2021

Draft introductory letter reviewed; added international, E.U. and U.S. labs to invitation list;  reviewed website content, drafted content for Meeting at a Glance, reviewed collaborative study timeline, began preparing protocol for first round.

              June 2, 2021

Finalize list of potential participants and letter advertising the study. Begin drafting protocol for 1st round of collaborative study.  Approve abstract and agenda for July  Working Group annual  meeting.

  • July 13, 2021

Finalize plans for NACRW Annual Meeting Working Group presentations and discussion forum. Review letter of invitation to potential study participants.  

  • November  10, 2021

Review of the November invitations sent to a list of ca 90 potential study participants from official control labs  -  Collation of responses of all interested labs has been starting - Round 1 for Meat and Milk is launched at the organizer lab at Anses-Fougeres with preparing pilot milk-meat extracts materials for stability study. 

  • April 29, 2020

Review performance requirements for multi-residue methods.

Discuss possible collaborative study. 

  • May 27, 2020

Subgroup reviews proposed collaborative study protocol. 

  • June 29, 2020

Subgroup proposes top 30 analytes to be studied in collaborative study.

  • July 23, 2020

Subgroup discusses details of proposed collaborative study including instruments, matrices, number of replicates, laboratories willing to prepare samples and data to be provided by participating laboratories.              

  • July 26, 2020

NACRW meeting cancelled. 

  • August 27, 2020

Subgroup meets to continue discussion of collaborative study specifics. 

  • October 29, 2020

Subgroup discusses the analytes and concentrations for each matrix

  • December 16, 2020

Subgroup assigns the collaborative study threshold concentrations for Top30 analytes in matrices (eggs, kidneys, meats, milks, livers, fishes).

  •   July 22, 2019 

Met at NACRW.  Discuss future work to evaluate the performance of multi-analyte   for regulatory laboratories.        

  •  September 11, 2019    

Met at AOAC. New members identified. Discuss definition of multi-residue/multi-class methods. Propose subgroup to develop a collaborative study.  

             





PLEASE CONTACT THE CHAIRS FOR MORE INFORMATION


Eric Verdon, 

Eric.VERDON@anses.fr


Sherri Turnipseed

sherri.turnipseed@fda.hhs.gov


 Goals of the NACRW Veterinary Drugs Working Group 

  • To identify Multi-Residue/Multi-Class Vet Drug Residue Methods (> 100 analytes) that would meet the needs of regulators. 
  • The NACRW Veterinary Drugs Working Group (VDWG) proposes to investigate veterinary drug screening methods which utilize LC-MS instrumentation to detect the presence of one or more regulated compounds at levels below the food safety relevant defined maximum levels.
  • Current project: VDR-WG to draft and review the process and agenda for a Collaborative Study in several rounds identifying methods and criteria relevant for goal described above.

VDR Resources

SANTE_12682_2019_Pesticides (pdf)Download
EU_Commission_Regulation_2019_1871_EC (pdf)Download
CXG_071e_2014_Veterinary_Drugs_Method_Performance_Criteria (pdf)Download
CXG_090e_Pesticides_method_performance_criteria (pdf)Download
2003_181_EC (pdf)Download
EU 2002_657_EC_EU_Vet_Drugs_Method_Performance_Criteria (pdf)Download
FDA Acceptance Criteria for Confirmation of Identity of Chemical Residues using Exact Mass Data within the Office of Foods and Veterinary Medicine (pdf)Download
FDA Guidelines for the Validation of Chemical Methods for the FDA FVM (pdf)Download

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